The APOE ϵ4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease

BR Cardoso; DJ Hare; M Lind; CA McLean; I Volitakis; SM Laws; CL Masters; AI Bush; BR Roberts

Journal article

The APOE ϵ4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease

BR Cardoso, DJ Hare, M Lind, CA McLean, I Volitakis, SM Laws, CL Masters, AI Bush, BR Roberts

ACS Chemical Neuroscience | AMER CHEMICAL SOC | Published : 2017

DOI: 10.1021/acschemneuro.7b00014

Abstract

The antioxidant activity of selenium, which is mainly conferred by its incorporation into dedicated selenoproteins, has been suggested as a possible neuroprotective approach for mitigating neuronal loss in Alzheimer's disease. However, there is inconsistent information with respect to selenium levels in the Alzheimer's disease brain. We examined the concentration and cellular compartmentalization of selenium in the temporal cortex of Alzheimer's disease and control brain tissue. We found that Alzheimer's disease was associated with decreased selenium concentration in both soluble (i.e., cytosolic) and insoluble (i.e., plaques and tangles) fractions of brain homogenates. The presence of the A..

View full abstract

University of Melbourne Researchers

Dominic Hare Author

Catriona McLean Author

Ashley Bush Author

Related Projects (2)

TRACING IRON FROM NEURODEVELOPMENT TO NEURODEGENERATION IN PARKINSON'S DEISEASE

Excessive brain iron can cause neurodegeneration in Parkinson's disease (PD). This project will examine a link between early-life iron expos..

Metalloproteomics: A new piece of the systems biology puzzle

Systems biology uses advanced analytical technology to study the complex chemistry of the living cell. Many cellular functions are the resul..

Grants

Awarded by Australian Research Council

Funding Acknowledgements

B.R.C. was supported by a Science without Borders (Ciencia sem Fronteiras) Fellowship. D.J.H. is a National Health and Medical Research Council Career Development Fellow (APP1122981). S.M.L., B.RR, A.I.B., and C.L.M. received financial support from the Cooperative Research Centre (CRC) for Mental Health (Grant ID: 20100104), an Australian Government Initiative. Tissues were received from the Victorian Brain Bank Network, supported by The University of Melbourne, Alfred Hospital, the Victorian Forensic Institute of Medicine, the National Health and Medical Research Council. We acknowledge funding from the Victorian Government's Operational Infrastructure Support Program and the Australian Research Council Linkage Projects Scheme (LP140100095, with Agilent Technologies).